Stories from the road: Trials and tribulations of the ISCB Student Council

The Student Council for the International Society for Computational Biology was established in 2004 to promote the development of computational biology among young scientists. The group runs events and programmes, as well as supporting the creation of Regional Student Groups.

Image Credit: Vignesh GPAs an official journal of the ISCB, PLOS Computational Biology is delighted to be publishing ‘Stories from the road: ISCB Student Council Collection’, a series of articles documenting the various activities of the ISCB student community and providing guidance to future generations of ISCB Student Council members. From the importance of creating a culture where networking is possible, to tips for workshopping ideas and problems, the series captures the experiences of young scientists.

“Collaborating with authors and contributors from dozens of countries around the globe has been an extremely interesting, challenging and rewarding experience,” says Thomas Abeel, one of the authors of the series. “Putting this series together has brought back some great memories, reinforced friendships and has re-taught some of the lessons we highlighted in these articles all over again.”

The collection’s primary authors and organisers were Thomas Abeel, Geoff Macintyre and Magali Michaut. Their own account of the council and the creation of the collection can be read here.

It is the journal’s hope that this collection will help spread some of the wisdom that the council has acquired over the course of a decade.

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This week in PLOS Biology

In PLOS Biology this week, you can read about a molecule with the potential to treat malaria, the remarkable diversity in sex determination and regulation of synaptic homeostasis.

 

Credit_NIAID

Malaria-infected red blood cell. Image credit: NIAID

Malaria is a mosquito-borne infectious disease which in 2010 killed up to 1.2 million people. The parasites that cause malaria live inside red blood cells, and while there secrete many different proteins that mold the host cells to their own purposes. An enzyme called Plasmepsin V is known to be involved in the correct secretion of these proteins. In new research, Brad Sleebs, Justin Boddey and colleagues showed that Plasmepsin V is essential for malarial parasite survival, and were able to design a molecule which could inhibit its activity. Although this molecule was needed at too high a concentration for it to be useful clinically, future refinements could lead to a useful drug. Read more in the accompanying synopsis.

 

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Image credit: pbio.1001899

Sex determination – isn’t it mostly about X and Y? This is one of several commonly held myths debunked by Doris Bachtrog, Jana Vamosi and co-authors in a new addition to our ‘Unsolved Mystery’ series. The authors discuss the myriad different mechanisms by which sex has evolved to be determined in eukaryotes. They survey our current understanding of the topic and identify important knowledge gaps.

 

Negative feedback is an important mechanism across many systems. One example is in the dampening down of excessive activity in neurons. New research by Seonil Kim and Edward Ziff highlights the importance of the calcium-dependent phosphatase calcineurin. Calcineurin activity is decreased when inhibition of neuronal excitability reduces calcium influx. This leads in turn to increased levels of phosphorylation and resulting stabilisation of AMPA receptors – a type of glutamate receptor that’s permeable to calcium, thereby closing the feedback loop.

 

Category: Biology, Cell biology, Cell signalling, Developmental biology, Disease, Evolution, Genetics, Infectious disease, Molecular biology, Neuroscience, PLOS Biology | Leave a comment

Meet the “PLOSSE” at ISMB 2014

Heading to the ISCB’s annual conference, ISMB 2014, July 11– 15, in Boston this year?  Swing by Booth 409 and say hello to PLOS!

PLOS Computational Biology staff Clare Weaver and Chris Hall will be manning the booth, alongside PLOS ONE Associate Editor Renee Hoch and Mei Yan Leung, Product Marketing Manager. They’re keen to answer your questions and hear your thoughts on Open Access, the journals and exciting projects such as PLOS Computational Biology’sOutside the Box”.

Image credit: PLOS

Image credit: PLOS

We’ll also be hosting “Meet PLOS” drop-in sessions on the evenings of Sunday 13th and Monday 14th July. In the same vein as previous years’ “Meet the Editor” sessions, these drop-ins are your opportunity to chat to editors across PLOS ONE and PLOS Computational Biology. Visit Booth 409 for more information on these events and to snag a free PLOS Computational Biology t-shirt before they’re all gone. This year’s shirt was designed by Ariel Afek who will be at ISMB presenting the work featured in his design.

Keep an eye out for PLOS Computational Biology editors across the conference and follow us on Twitter for live updates on events that they’re involved in. Here are some to get you started:

Friday 11th July

Sunday 13th July

  • Christine Orengo and Lonnie Welch host a special session on “Communities of Special Interest”, which includes contributions from Hilmar Lapp and Fran Lewitter
  • Celebrating Nobel prize winners Martin Karplus and Michael Levitt, and reflecting on their enormous impact on those they have mentored, Steven Brenner and Mark Gerstein take part in a Special Session, and Roland Dunbrack gives a Special Talk
  • Teresa Przytycka presents her paper “Dissecting Cancer Heterogeneity with network based approach”

Monday 14th July

Tuesday 15th July

There’s still time to register for ISMB 2014 online if you’ve not yet done so. We look forward to seeing you in Boston!

Category: Announcement, Community, Computational biology, Conference, News, Open access, Outreach, PLOS Computational Biology | Tagged , , , | Leave a comment

This week in PLOS Biology

In PLOS Biology this week, you can read about meeting biodiversity targets, sequencing microbial life, a new piece of the Nodal pathway, early problems in Huntington’s disease and how fly larvae choose to eat or crawl.

 

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Image credit: pbio.1001892

In a new research article this week, Oscar Venter, James Watson and colleagues argue that we need to approach protected areas expansion in a way that conserves the maximum number of endangered species. Currently much of the land protected is cheap but relatively species-poor. The authors analysed the number of threatened vertebrate species which would be covered by the implementation of the Aichi biodiversity target to protect 17% of the globe’s land surface by 2020. The results showed that only 249 more species would benefit compared to current reserves. They argue that as protecting more species-rich land brings a proportionately larger benefit in terms of biodiversity conservation, a ‘happy medium’ can be found to achieve these targets. Read more in the accompanying synopsis.

 

Bruce Anderson (University of Stellenbosch) dinoflagellates

Dinoflagellates glow blue after a chemical reaction is triggered by the wind. Image credit: Bruce Anderson (University of Stellenbosch)

Molecular sequence data are essential for making sense of the spectacular diversity of microbial life on our planet.  We’ve made a start, but there are significant taxonomic biases in the eukaryotic organisms chosen for sequencing so far, usually limited to those of medical or biotechnological significance. Resources are particularly scarce for marine organisms, and a new Community Page by Alexandra Worden, Patrick Keeling and members of the MMETSP Consortium highlights The Marine Microbial Eukaryotic Transcriptome Sequencing Project – a resource of 700 transcriptome sequences from marine microbial eukaryotes to help understand their role in the world’s oceans.

 

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Image credit: pbio.1001890

In mammalian developmental biology, the Nodal signalling protein is well-known for its importance in promotion of differentiation in extra-embryonic tissues (such as the placenta). Now new research by Costis Papanayotou, Jérôme Collignon and colleagues has found a novel enhancer within the Nodal gene which is involved in activating Nodal expression in early stages of development (in response to pluripotency factors and SMAD signalling) and orchestrating the activation of other Nodal enhancers later on.

 

Neurodegenerative diseases such as Huntington’s cause damage to neurons before symptoms even appear. In new research, Cendrine Tourette, Christian Neri and colleagues showed that the Wnt receptor Ryk is involved in the pathways of neuronal cell homeostasis. Levels of Ryk were increased in mouse models of Huntington’s disease, a finding that has clinical implications for potential early-stage restoration of neurons’ capacity to resist damage in patients with this and related diseases.

 

In the animal kingdom, two of the most essential behaviours are locomotion and feeding, but how is the choice between these two made? Andreas Schoofs, Michael J. Pankratz, and colleagues show that a single cluster of neurons in the fly central nervous system simultaneously suppresses feeding behaviour and induces food-seeking movements in larvae. These neurons, characterised by their expression of the neuropeptide ‘hugin’, transmit inputs from higher brain centres to motor centres. Read more in the accompanying synopsis.

 

Category: Biology, Cell biology, Cell signalling, Computational biology, Developmental biology, Disease, Ecology, Environment, Genomics, Microbiology, Molecular biology, Neuroscience, PLOS Biology, Research | Leave a comment

Evolution Conference: Bret Payseur

As part of its mission to encourage engagement within the genetics community, PLOS Genetics is sponsoring a number of conferences and meetings this year. In order to raise awareness about these conferences and the researchers who attend them we are featuring a number of these conferences on Biologue, with posts written by the organizers or PLOS Genetics editors who are involved.

 The conference of the Society for the Study of Evolution started on the 20th of June, and is taking place in North Carolina. Bret Payseur, PLOS Genetics editor, says a few words about the conference and why he finds it exciting.

The Society for the Study of Evolution is meeting June 20-24 at the Raleigh Convention Center. This is a joint meeting with the Society of Systematic Biologists and the American Society of Naturalists. Participants include faculty, postdoctoral researchers, graduate students, and undergraduates from around the world. The meeting impeccably organized. I am delighted that PLOS Genetics is a sponsor of this exciting meeting.

Image credit: Kevin Dooley Flickr CC-BY

A unifying theme of the conference is biodiversity. Collectively, presenters provide portraits of evolution in organisms from across the tree of life. Both the patterns of biodiversity and the evolutionary processes that created them are of interest. Big, longstanding questions are discussed and debated through an impressive amalgamation of empirical and theoretical approaches. How are species related to one another? How do new species arise? What is the genetic basis of trait evolution? What are the evolutionary and ecological determinants of biodiversity? How do organisms adapt to their environments? More practical issues are also at the forefront of the meeting, including the prospects, challenges and limitations of genomic data for evolutionary biology. The smorgasbord of offerings is enough to inspire anyone interested in biological variation.

Of all the scientific meetings I attend, this is my favorite.

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PLOS Biology Paper Wins Omenn Prize for Viral Evasion Story

We talk to the authors of a PLOS Biology research article published last May that has just won the Omenn Prize for the best article published in 2013. The Omenn Prize is awarded annually by the Evolution, Medicine, & Public Health Foundation to authors of articles related to “evolution in the context of medicine and public health,” and the winner was picked from a tough long-list of 47 papers. Four other papers, including two from our sister journal PLOS Pathogens, were cited for “honorable mention” (Graves et al. Huijben et al.).

 

The PLOS Biology paper looks at how an essential mammalian protein – the transferrin receptor, TfR1 – evolves in the face of contrasting selective pressures. TfR1 is a protein that sits on the membrane of our cells and mediates the regulated uptake of iron. TfR1 is stuck in the horns of a dilemma. On the one hand, it has to be able to bind its functional partners – the iron-loaded plasma protein transferrin, and a negative regulator protein called HFE; this requirement constrains the sequence and structure of TfR1 through evolutionary time. On the other hand, it has to evade viruses that exploit its handy cell-surface location, such as arenaviruses and the rodent retrovirus MMTV.

 

TfR1 can carry on binding transferrin and HFE while dodging viruses. DOI: 10.1371/journal.pbio.1001571

TfR1 can carry on binding transferrin and HFE while dodging viruses. DOI: 10.1371/journal.pbio.1001571

The authors compared sequences of TfR1 from various mammalian hosts and then expressed them on the surface of cells to check a) their ability to confer vulnerability or resistance to MMTV and arenaviruses such as Machupo, Junin and Guanarito virus and b) their ability to bind to transferrin. This image from the paper summarises the central finding – how TfR1 (green) manages to square this circle by evolving rapidly (red) to change the outer surfaces that are hijacked by viruses while keeping constant the central surfaces that it uses to bind transferrin and HFE (purple, blue).

 

First author Ann Demogines and lead author Sara Sawyer – both from the University of Texas at Austin – told us how the study first arose and then evolved into the paper that you can now read on our website.

 

Sawyer recalls the exact point at which the project started: “In the first year of my faculty position, Welkin Johnson invited me to give a talk at the New England Primate Research Center.  While I was there, I had a 45 minute meeting with his colleague, Mike Farzan [also a co-author]. Mike had just discovered TfR1 as the cellular receptor for arenaviruses, and suggested to me that this might be a molecule that is engaged in an evolutionary arms race.  While ideas like this often arise out of conversations between scientists, I remember having a gut reaction that this was something worth pursuing.”

 

Amino acids marked in red track virus binding sites on TfR1 (blue, grey) DOI: 10.1371/journal.pbio.1001571

Positively selected amino acids (red) hit the virus binding sites on TfR1 (blue, grey) DOI: 10.1371/journal.pbio.1001571

Demogines, who received $5000 from the Foundation, describes how the spectacular arrangement of the evolutionarily selected sites emerged: “I am still amazed to this day by the results of the evolutionary analysis.  We were able to take DNA sequence from just 7 species and computationally predict six sites under selection.  These sites were scattered on the linear diagram of the protein, and didn’t make much sense to us. But, when we placed them onto the 3D crystal structure they formed a beautiful ridge going straight down the outer surface of the receptor.  That was a great day in the lab.  We knew this had to mean something!”

 

Demogines goes on to think about the implications of her paper and related studies: “This work really gets me excited about the future of evolutionary analysis applied in biomedical research.  As we collect the genome sequences from more and more species, especially rodents and bats which are major reservoirs for zoonotic and potentially zoonotic viruses, we should be able to do this type of analysis more and more.  This type of analysis has many applications: allowing us to identify critical cofactors involved in the viral lifecycle, viral binding sites, and potentially novel drug targets. It can also be used to study interactions with bacterial pathogens, although this has not yet been extensively explored.”

 

If you’d like to find out more about this elegant study, why not read the article itself, or the accompanying Primer written by John Coffin:

 

“Dual Host-Virus Arms Races Shape an Essential Housekeeping Protein” by Ann Demogines, Jonathan Abraham, Hyeryun Choe, Michael Farzan and Sara L. Sawyer. DOI: 10.1371/journal.pbio.1001571

“Virions at the Gates: Receptors and the Host–Virus Arms Race” by John M. Coffin. DOI: 10.1371/journal.pbio.1001574

 

 

Category: Biology, Computational biology, Evolution, Microbiology, News, PLOS Biology, Research | Leave a comment

This week in PLOS Biology

In PLOS Biology this week, you can read about interdisciplinary community building, how yeast cells deal with stress, 3D printing and conservation of the Antarctic.

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Image credit: pbio.1001885

During their lifetime, cells accumulate damage such as aggregated proteins, which is inherited by the daughter cells when the mother cell divides. In cells that normally divide symmetrically, such as the yeast Schizosaccharomyces pombe it has been shown that under stress conditions this can change and the cells switch to asymmetric division. Miguel Coelho, Iva Tolić and colleagues have shown in a new study how this adaptively valuable transition is achieved. Under stress, more and larger clumps of protein are created, which after one or two cell divisions end up in one huge cluster – this can only be passed onto one daughter cell, leaving the other pristine. Read more in the accompanying synopsis.

 

This week a Community Page by Holly BikDavid Coil and Jonathan Eisen highlights the Microbiology of the Built Environment Network (microBEnet), which was formed as an experiment in interdisciplinary community building. It aimed to bring together investigators and stakeholders in a new area of research: the microbiology of the built environment (MBE). This field was born of the observation that as modern humans we spend most of our time indoors, and yet we know little about the countless microorganisms that exist within buildings.

 

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Image credit: pbio.1001882

3D printing, originally developed for plastic and metal manufacturing, now represents high hopes for applications to human tissue and organ engineering. In his Essay, Jordan Miller discusses the key challenges that remain in this endeavour, and the conceptual targets on the horizon. Examples of possible opportunities that are highlighted include building physiologically relevant models of disease and testing drugs on human tissues fabricated with 3D printers.

 

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Image credit: pbio.1001888

In their Perspective on the Antarctic, Steven Chown, Justine Shaw and colleagues argue that with a surge in visitors, Antarctica’s ice-free land needs better protection from human activities. Global comparisons show that Antarctica’s terrestrial biodiversity is poorly protected; only 1.5% of its ice-free regions were found to be protected formally. They highlight the fact that this means Antarctica currently falls well short of the Aichi Biodiversity Targets – an international biodiversity strategy that aims to reduce threats to biodiversity, and protect ecosystems, species and genetic diversity.

 

Category: Biology, Biotechnology, Cell biology, Climate, Community, Ecology, Environment, Microbiology, PLOS Biology, Research | 2 Comments

This week in PLOS Biology

This week sees the launch of a new PLOS Biology CollectionThe Promise of Plant Translational Research, and a research article into a possible new drug target for rheumatoid arthritis.

 

Chun thumb1

Image credit: pbio.1001881

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation in the synovia of the joints. Its causes are still somewhat unclear, and there’s an urgent need for new and effective treatments. New research by Je-Hwang Ryu, Jang-Soo Chun and colleagues in PLOS Biology this week explored the role of HIF-2α, a transcription factor involved in the response to hypoxic conditions; hypoxia in the inflamed synovium is a known feature of RA. This new research showed that in mice, HIF-2α is markedly increased in the tissue lining the RA-affected joints. Interestingly, when it was overexpressed in normal mouse joint tissue, HIF-2α caused RA-like symptoms by itself. The authors conclude that HIF-2α could therefore be a therapeutic target for treatment of this disease.

 

Gates collection thumbnailWith the world’s population projected to rise from the current 7 billion to 9 billion by 2040, feeding these people from the same limited land and water resources will need considerable technology-driven advances in agricultural productivity. This week PLOS launches a new Collection, marked by 7 inaugural articles* in PLOS Biology, with the aim of encouraging submission of relevant research to Open Access venues like the PLOS journals, where they can be read by those who most need to. Read the Biologue blog post “How Will We Feed the World?” by Roli Roberts and our Editorial for more details.

 

*New articles in PLOS Biology published as part of “The Promise of Plant Translational Research”:

 

New Horizons for Plant Translational Research: Jeffrey Dangl, Sophien Kamoun, Susan McCouch and Jane Alfred present an overview of the Collection.

Moving beyond the GM debate: In this Perspective, Ottoline Leyser calls for the public to move on from the common logical fallacy that anything natural is good, and anything unnatural is bad, and addresses the misconception that GM, as a technique, is specifically and generically different from other crop genetic improvement techniques.

Genome Elimination: Translating Basic Research into a Future Tool for Plant Breeding: This Perspective by Luca Comai discusses the contribution of the late Simon Chan to the invention of genome elimination, and ponders the future of his approach as a way of streamlining the optimisation of plant genotype.

 

Finally, four Essays explore the technological basis and real-life application of genetic and genomic research, genome editing, whole-genome sequencing and metabolic engineering to the improvement of food crops:

 

Lab to Farm: Applying Research on Plant Genetics and Genomics to Crop Improvement by Pamela Ronald.

Precision Genome Engineering and Agriculture: Opportunities and Regulatory Challenges by Daniel Voytas and Caixia Gao.

Harvesting the Promising Fruits of Genomics: Applying Genome Sequencing Technologies to Crop Breeding: by Rajeev Varshney, Ryohei Terauchi and Susan McCouch.

Key Applications of Plant Metabolic Engineering by Warren Lau, Michael Fischbach, Anne Osbourn and Elizabeth Sattely.

 

 

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How Will We Feed the World?

Gates collection thumbnailPLOS has just launched a new Collection, “The Promise of Plant Translational Research”. Here’s why we did it, and what we hope to achieve.

 

The human race has a very serious problem; so serious that millions will die unless we solve it. It all started about 10,000 years ago. Up until then we’d lived as hunter-gatherers, and our humble lifestyle limited our numbers. But then we started to explore the benefits of exploiting the land more effectively, and agriculture was born. This technological suite of seed collection, sowing, irrigation, weeding and harvest allowed the same land to support many more of us.

 

Over the millennia we bred better crops (hexaploid wheat from emmer, maize from teosinte, paddy rice from Oryza rufipogon), systematically mechanised most aspects of the process (ox-drawn plough, seed drill, combine harvester), and artificially fertilised the soil (animal manure, the Haber process). And of course more food means more kids, and more kids need… You get the picture – a snowballing dependency on ever-improving the efficiency of our food production. All grown – by plants – using the solar energy that hits our finite planet.

 

Image Credit: Flickr user Frederic

Image Credit: Flickr user Frederic

The problem is that while population increases exponentially, food production increases only arithmetically. Seven billion souls – and counting – currently share our planet, with a projected population of nine billion by 2040. While the Green Revolution of the late 20th century went some way to keeping productivity in pace with demand, feeding these extra mouths will require a substantial increase in agricultural output while competing with the burgeoning population for valuable land and water resources. Furthermore, if a population is able to achieve food security, along with health care and education, people will tend to limit family size of their own accord, keeping population in check. So working to achieve food security for the world’s billions offers a constructive way out of the debacle.

 

PLOS recognises that many of these problems (and the need for attendant solutions) impinge directly on those people and countries least able to break through the pay-wall that many scientific journals use to guard their content. For translational plant research, more than most fields,  Open Access is crucial to maximise the availability and utility of research by those who need it most. We, and the rest of the scientific community, can facilitate information and knowledge exchange by promoting Open Access.

 

What our Collection aims to do is a) open up the debate about the urgent need for plant translational research, b) discuss the ways in which scientific research and technological advance can meet this need, and c) encourage the submission of such research to Open Access journals, like those of the PLOS family.

 

What can you do? Firstly, read the inaugural articles of the Collection that we’ve just published in PLOS Biology (see below). I’d recommend starting with the magnificently punchy Perspective by Ottoline Leyser, which lays out the scale of the problem and exhorts us to ignore red herrings and concentrate on the pressing task in hand. Secondly, submit your translational plant research to one of our journals (PLOS Biology, PLOS Pathogens, PLOS Genetics, PLOS Computational Biology and PLOS ONE are the most relevant) and make sure that the people who need to read it can!

 

We’re grateful to Jeffrey Dangl, Sophien Kamoun and Susan McCouch, who as academic editors of the Collection have provided us with advice and guidance throughout, including helpful comments on this blog post. We’d also like to thank the Bill and Melinda Gates Foundation for supporting the Collection.

 

 

New articles in PLOS Biology published as part of “The Promise of Plant Translational Research”:

 

New Horizons for Plant Translational Research: Jeffrey Dangl, Sophien Kamoun, Susan McCouch and Jane Alfred present an overview of the Collection.

Moving beyond the GM debate: In this Perspective, Ottoline Leyser calls for the public to move on from the common logical fallacy that anything natural is good, and anything unnatural is bad, and addresses the misconception that GM, as a technique, is specifically and generically different from other crop genetic improvement techniques.

Genome Elimination: Translating Basic Research into a Future Tool for Plant Breeding: This Perspective by Luca Comai discusses the contribution of the late Simon Chan to the invention of genome elimination, and ponders the future of his approach as a way of streamlining the optimisation of plant genotype.

 

Finally, four Essays explore the technological basis and real-life application of genetic and genomic research, genome editing, whole-genome sequencing and metabolic engineering to the improvement of food crops:

 

Lab to Farm: Applying Research on Plant Genetics and Genomics to Crop Improvement by Pamela Ronald.

Precision Genome Engineering and Agriculture: Opportunities and Regulatory Challenges by Daniel Voytas and Caixia Gao.

Harvesting the Promising Fruits of Genomics: Applying Genome Sequencing Technologies to Crop Breeding: by Rajeev Varshney, Ryohei Terauchi and Susan McCouch.

Key Applications of Plant Metabolic Engineering by Warren Lau, Michael Fischbach, Anne Osbourn and Elizabeth Sattely.

 

 

 

 

Category: Announcement, Biology, Climate, Community, Ecology, Environment, Genetics, Genomics, Open access, Plant biology, PLOS Biology, PLOS Computational Biology, PLOS Genetics, Research | 5 Comments

PLOS Comp Biol style for 2014: Nonconsensus binding

PLOS Computational Biology is delighted to reveal the winner of this year’s t-shirt design competition: Ariel Afek, from Ben-Gurion University! Ariel’s design “Nonconsensus Protein-DNA binding” will appear on t-shirts available from the PLOS booth at the ISMB 2014 conference in Boston. PLOS Computational Biology t-shirts have become a popular staple of the journals’ presence at ISMB over the past six years, so make sure you drop by the PLOS booth to grab one before they’re gone!

Image credit: PLOS

Image credit: PLOS

The winning design is based on the phenomenon of “Nonconsensus Protein-DNA binding”, where proteins bind to DNA in the absence of a binding site. Normally proteins require specific sequences (called motifs) to be present in an area of DNA before they can bind to it, but in the scenarios modelled by Ariel and his co-authors and depicted in the design, different proteins can bind to DNA in various genomic locations which lack motifs. The initial image appeared as a way for Ariel to help explain the process at a conference and, with feedback from friends, was developed into the final design.

Ariel and his co-authors have modelled this form of binding in the yeast genome, and will be presenting experimental results and bioinformatics analysis on this topic as a poster at ISMB, in the “Functional Genomics” category.

The PLOS booth will be open at ISMB 2014 from 12th July to 15th July. We’d love to hear your feedback and suggestions for the journal, so please come and say hello!

 By Arielle Bennett, Publications Assistant, PLOS Computational Biology 

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