This Week in PLOS Medicine: Clinical trial reporting; ED and cardio disease; NCDs in LMICs

With the close of the month, PLOS Medicine publishes four new articles, including a research article on reporting of clinical trials and an editorial expanding on the subject.

The PLOS Medicine editors discuss the recent initiative from the European Medicines Agency to commit to releasing clinical trial data and how important such moves are for rebuilding trust between the pharmaceutical companies and society.

Using documents obtained through litigation, S. Swaroop Vedula and colleagues compared internal company documents regarding industry-sponsored trials of off-label uses of gabapentin with the published trial reports and find discrepancies in the reporting of analyses.

In a prospective Australian population-based study linking questionnaire data from 2006-2009 with hospitalization and death data to June 2010 for 95,038 men aged ≥45 years, Emily Banks and colleagues found that more severe erectile dysfunction was associated with higher risk of cardiovascular disease.

Shah Ebrahim and colleagues argue that more research on non-communicable diseases (NCDs) in both high-income countries and low- and middle-income countries can result in mutual benefits and will help better address the growing burden of NCDs.

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