The Science of Mysteries: An Overdose of Strychnine

One day on Twitter, some science bloggers who began life on the dark side, in the humanities, happily discovered a shared taste for classic mystery writers.  We thought we might write a series of posts, all on the same day, about the science in mystery books and so we did exactly that in December. And it was so much fun we decided to do it again.

My colleagues in crime, Jennifer Ouellette and Ann Finkbeiner, have looked to the great crime novelist, Dorothy L. Sayers, to explore other areas of science.  At her blog, The Last Word on Nothing, Ann writes about post-traumatic stress syndrome in the aftermath of World War I. And at Cocktail Party Physics, Jennifer takes another Sayer’s book as the starting point for a journey through the physics of music.

As for me, this time around, I found a combination of Agatha Christie and the terrifying toxicity of strychnine to be an irresistible combination…..


Courtesy: National Library of Medicine

There is altogether too much strychnine about this case – The Mysterious Affair at Styles, Agatha Christie,  1920.

In the midst of World War I – or so the story goes – a young Englishwoman received a literary challenge from her sister. Could she write a mystery novel in which the true villain was impossible to guess?

The response to that challenge was a tale of strychnine and murder that launched one of the most successful careers in crime fiction. No exaggeration whatsoever:  the book was published, after several years of publisher hunting, in 1920; its title is The Mysterious Affair at Styles; its brilliant fictional detective is called Hercule Poirot and its author (30 years old at time of publication) is named Agatha Christie.

Christie would go on to write about 65 detective novels and some 14 short story collections (not to mention the occasional play) before her death in 1976. Over the years, sales of her books reportedly have reached close to four billion. But for purposes of this poison-obsessed blog, let us stipulate her dazzling success, her famed fictional characters, and even her famously intricate plotting techniques. Let us focus instead about another celebrated Christie characteristic: she also was obsessed with poisons.

They were her weapon of choice, so much so that a University of Texas pharmacology professor even wrote a book on the subject, titled The Poisonous Pen of Agatha Christie , a survey of the 30 odd poison murders in the mystery novelist’s 66 books. The poisons spanned such a range that the professor felt compelled, as one reviewer noted,  to include a 76-page alphabetical listing of all the toxic compounds – from strychnine to arsenic to thallium to taxine – and all the related chemistry in the Christie ouevre.

I’ve been reading Christie and admiring her devious plotting since I was a teenager given to raiding my mother’s prized collection of murder mysteries.  Her work and others from  the 1920s and 1930s, a era sometimes called the golden age of detective fiction, always fascinated me. The wickedness of the poisons, the cold calculation of the poisoners in the stories, all influenced my own non-fiction book, The Poisoner’s Handbook, which takes a narrative look at forensic toxicology in that same time period. In an earlier Science of Mysteries post, I paid tribute to another brilliant crime novelist of the time, Dorothy L. Sayers and her well-researched study in arsenic, Strong Poison.

But no crime novelist wrote about poison with such knowledge and enthusiasm as Christie, who once said: “Give me a decent bottle of poison and I’ll construct the perfect crime.” In fact, at the time that Christie began work on A Mysterious Affair at Styles, she had been working as a wartime nurse, had been employed in a hospital pharmacy ( then called a dispensary), and had studied for and passed  a test to become a member of the Society of Apothecaries.

So she began her career with a subject she knew well. And the plot of this first novel involves the strychnine poisoning of Emily Inglethorp,  a wealthy and dictatorial elderly woman living at Styles, a classic English country house. The soon-to-be victim is recently remarried to a mysteriously bearded and slightly smarmy younger man. The marriage has thrown into disarray the inheritance plans of her two step-sons who both also live in the house. Residents also include the exotically beautiful wife of the older son and the love interest of the younger, a nurse who happens  to work in a hospital dispensary, and assorted other suspects.

In fact, it’s very much a first novel,  a writer finding her style. Christie would grow into an author with a smooth style,  skilled in elegant misdirection. The Mysterious Affair at Styles has the misdirection without the elegance. It’s cluttered with quarrels, accusations, footprints, spies, cheating husbands, cheating wives and other misunderstandings among the red herrings litter the landscape. But in my particular version of fandom,  all can be forgiven in admiration of the precise (and elegant) chemistry that underlies the story.

Continue reading »

Category: murder mystery, poison, Speakeasy Science, The Poisoner's Handbook | Tagged , , , , , , , , , , , | 16 Comments

New Blog, New Name, New Home

I’m joining the Wired Science Blog network as of today and starting there with a new blog name – Elemental – that I think better reflects the way I’ve evolved as a writer fascinated by with our chemical world. As ever interested in poisons though – my first post is a  look at the Dalai Lama’s recent revelation that China might be trying to poison him. I hope you’ll enjoy it, and my continued work there.

But although I’m excited about starting this new venture I also admit some sadness. Because this is a good-bye note, a farewell to my old blog, Speakeasy Science, and to my time at PLoS.
I’ve been a blogger here since 2010. I’ve had the opportunity to write about everything from pepper spray, to arsenic murders, to the haunting occupational health tragedy of the Radium Girls to my ongoing crusade against the ridiculous phrase “chemical free” (had to sneak that in). I’ve been honored for my work here; my post, The Trouble With Scientists, was anthologized in Best American Science Writing 2011.

And I’ve been privileged to be a colleague of some of the smartest bloggers in the business, including Steve Silberman, John Rennie, Emily Anthes,  Jessica Wapner, Misha Angrist, Hilary Rosner, David Kroll…well, the list is long and superb. I’m grateful for their support and kindness and wisdom.

PLoS has  also been ever supportive of all my inquiries and endeavors.  When I decided to make the move, Liz Allen, who oversees the blog network, asked me to share her goodbye note as well:

PLoS Blogs has been privileged to host Pulitzer Prize winning writer Deborah Blum on our Network for the past two years. During this time she has consistently contributed lively and meticulously researched posts that set high standards for all the blogging scientists and science writers who follow her. What I’ve found most impressive about her research blogging has been Deb’s ability to take a newly published study on chemistry, toxic substances or a trending media topic, explain it thoroughly, and immediately put whatever new information it offered into a relevant context for scientists and lay persons alike. And she managed to do all this with good humor and grace. We’ll miss her here, but wish her well in her new endeavor.

It’s been an honor. But I think it’s good for writer like myself to take on new challenges, to experiment with story-telling in new ways, and to reach out to other audiences, as I hope to do at Wired. As you know, that’s also home to a fantastic science blogging network and I’m glad for the opportunity to test my chemical wings there in new and, I hope, intriguing ways.

So stay in touch, okay?

Category: Speakeasy Science | Tagged , , | 15 Comments

Nicholas Kristof and the Bad, Bad Chemical World

Source: Silsor, Wikimedia Commons

I’m a long-time fan of New York Times columnist Nicholas Kristof. To be more specific, I’m a long-time fan of his work in social justice journalism, his passionate reporting of problems of others ignore, his dedication to helping people in traumatized regions of Africa.

It’s outstanding work and, oh, how I wish he would stick to it. Because his secondary crusade of the last few years, you know, the one against evil industrial chemicals, is really starting to annoy me. This is not saying that he’s entirely wrong – there are evil industrial chemicals out there. And, in many cases, they aren’t as well researched or as well regulated  as they should be.

But if we, as journalists, are going to demand meticulous standards for the study and oversight of chemical compounds then we should try to be meticulous ourselves in making the case. And much as I would like it to be otherwise, I don’t see enough of that in Kristof’s chemical columns. They tend instead to be sloppy in their use of language, less than thorough, and chemophobic enough to undermine his legitimate points.

In the matter of chemophobia, I’d like to refer you to a piece I wrote two years ago following a Kristof column of May 2010: Here’s a short excerpt: “After proposing a link between too much chemistry and not just cancer but diabetes, obesity and autism, Kristof goes on to say “This is not to say that all chemicals are evil…”.  I still cannot read that line without rolling my eyes.

Because, how do you define a good or an evil chemical? Hydrogen (H) is an essential element of water (two hydrogen atoms, one oxygen= H2O) which comprises more than 90 percent of our own bodies and sustains most of life on earth. It’s also found in the incredibly poisonous formula of HCN (hydrogen cyanide). Oxygen in a doublet (O2) keeps us alive. In a triplet (O3) it’s known as a toxic pollutant called ozone. And while ozone is dangerous in ambient air it’s also essential in the upper atmosphere for blocking ultraviolet radiation from the sun.

Yes, there are unambiguously dangerous materials – the naturally occurring element lead (Pb) comes to mind. But mostly, it makes no sense to randomly throw the word “chemical” around as if it had any meaning in terms of human health. And when we have influential journalists using the word chemical as a synonym for spawn-of-Satan then we have journalists who’ve missed their opportunity to inform the public as to what is a legitimate risk and what is not.

Instead we – by which I actually mean Kristof  – run the risk of teaching nothing more than a generalized chemical anxiety.  To this instance, I cite another of his columns from 2010, “Do Toxins Cause Autism?”, which notes the upward trend in autism diagnoses and speculates that “one culprit may be chemicals in the environment.”  As our environment is, in fact, nothing but chemical compounds this fails what I might call the helpfulness test. Or, as the blogger Polly Palumbo of Momma Data put it, “How do you scare parents silly? Mention toxins, prenatal development and autism together.”

Which brings me to Kristof’s column of this month, which is titled “How Chemicals Change Us.” Right. But let’s not just roll our eyes. Let’s try inquiring as to what he means. So, you say, which “chemicals” do you mean precisely? He answers in the first paragraph:  “common hormone producing chemicals”? Oh, you respond, and what are those precisely? “A widely used herbicide,” he replies in the second graph, one that apparently feminizes fish and gives alligators tiny penises.  Oh, you try again, what herbicide exactly? But here, reader, you are just out of luck. Because he is just not going to tell you that. Not in that graph or anywhere in the piece.

I’m going to guess that it’s (a) the herbicide Atrazine which was linked ten years ago to “hermaphroditic, demasculinized frogs.”  But it could be (b) Roundup, instead, according to this one of many scientific studies on that subject.  Or it could be (c) another glyphosate pesticide. Glyphosate (a chemical cocktail of carbon, nitrogen, hydrogen, oxygen and phosphorus) is the central ingredient in herbicides such as Roundup. It’s also the endocrine disruptor in question,  the actual reason for concern. Or it could be (d) all of the above.  You tell me, reader, because the New York Times column doesn’t.

Kristof does cite some other endocrine disrupting compounds here such as BPA, best known for its use in plastic bottles and packaging,  and perfluorooctanoic acid (PFOA), used in everything from non-stick cookware to fire-retardant materials. But he breezes through their possible risks. Oddly, the one specific claim he makes against PFOA is an iffy study suggesting that prenatal exposure could, possibly, make girls – but not boys – overweight later in life. He ignores entirely a recent finding that the compound may be a more potent carcinogen than had been suspected.

You would think that a writer who wants to win a fight with “Big Chem” (as Kristof refers to the makers of these compounds) would choose the best ammunition at hand, wouldn’t you? Perhaps he needs a better researcher. Or perhaps, as Palumbo suggests at Momma Data, he needs a better fact-checker.  Or perhaps he needs to consider what he’s really trying to accomplish here.

Consider the conclusion to his most recent piece. He quotes a government scientist who no longer microwaves his food in plastic and avoids canned food (presumably because cans are lined with BPA although that isn’t clear here). And then he adds:”I’m taking my cue from the experts and I wish the Obama administration would as well.”

That the Obama administration would what exactly? Abandon canned food or better regulate regulate toxic chemical compounds? Are we talking household hints or policy implications?  If I didn’t believe we actually need smarter, more thoughtful regulation of toxic compounds, I wouldn’t find Kristof on chemicals so annoying. He’s wasting his opportunity and his outstanding platform on this half-researched, half-thought out muddle of a crusade.  I wish he would focus and do it right. Or not do it at all.

Category: chemistry, consumer protection, Speakeasy Science | Tagged , , , , , , , , , , | 76 Comments

The Eternal Hour of Lead

This is the Hour of Lead-
Remembered, if outlived,
As Freezing persons, recollect the Snow-
First – Chill – then Stupor – then the letting go –

When 19th century poet Emily Dickinson wrote those lines, she was describing the terrible paralysis of grief. A good century later, analysts for the Environmental Defense Fund, would also note that the last line “aptly describes some of the symptoms of lead intoxication.”

I’ve always suspected that they also just liked the poem and wanted to use it – certainly that’s partly my motive here. But I’ve also been thinking about one phrase in Dickinson’s verse because it seems to me, recently, that as a human society we seemed perpetually caught – by which I mean poisoned – in an endless” hour of lead.”

The chemical symbol for lead is Pb, from the Latin word “plumbum” which referred to a malleable metal. The term plumbing comes from the use of lead pipes by the Romans; a plumber fixes them, a plumb bob refers to a lead weight, a plumb line is pulled straight by such a weight. An old-fashioned term for lead poisoning is plumbism. We are surrounded by references to what is arguably the most important poison in human history.

Many scholars have argued, for instance, that the plumbum-loving Roman empire – enthusiastically using lead pipes, bottles, and wine cups, leaded cosmetics and paint – came to its end partly due to lead-poisoning of its upper classes. One U.S. Environmental Protection Agency paper on the history of lead poisoning, cites “the conspicuous pattern of mental incompetence that came to be synonymous with the Roman elite” as evidence of lead’s destructive effects.

Interestingly, the EPA paper also cites poetry to illustrate the evils of lead poisoning, a scrap of anonymous verse, attributed to a Roman hermit and translated in 1829:
The feeble offspring curse their crazy sires,
And, tainted from his birth, the youth expires.

The key points there being, of course, crazy sires and dead children. “No safe blood lead level has been identified,” notes a U.S. Centers for Disease Control and Prevention (CDC) backgrounder on exposure risks. Lead is a broad spectrum poison – it interferes with enzyme production, especially enzymes needed by red blood cells, and is known to cause lethal anemias. It targets neurons, disrupting the production of neurotransmitters such as glutamate (which plays a key role in learning by enhancing plasticity). It deposits itself into bones and stays there – the half-life of lead in human bones is up to 30 years. Muscle weakness, numbness and tingling, nausea, severe stomach pain, depression, fatigue, sleeplessness, loss of libido – all are symptoms of lead poisoning and all speak to its ability to impact every part of the body.

Lead banding (deposits) in leg bones

The Romans weren’t the only major civilization from our past to be affected by lead poisoning. Last summer, environmental scientists in Japan reported the results of an investigation into lead exposure in the Edo period, which lasted from 1603 to 1867, a time when the country was dominated by shogun leaders, and laws enforced by an aristocratic class of samurai warriors.

According to Tamiji Nakashima, an anatomist at the University of Occupational and Environmental Health in Kitakyushu, the investigators studied the remains of samurai men, their wives and children, about 70 in total. Earlier tests had found unusually high levels in the women compared to men; the last study looked at the children. The researchers tested for lead in rib bones, x-rayed the childrens’ arm and leg bones looking for signs of lead poisoning.

The Japanese scientists had already concluded that the lead levels in women were directly related to the white face paint popular in aristocratic circles, which turned out to be loaded with lead. They wondered if exposure to the same material might have harmed the children and the new results showed them precisely right; they found evidence of lead levels more than 120 times background level as well as bands of lead deposits in the bones.

Nakashima and his colleagues believe that the children were poisoned by touch, as they were fed, hugged, carried by their mothers, the lead-rich paint rubbed off on them. They also speculate that the gradual lead-poisoning – with its inevitable taint of death and disability – helped put an end to the shogunate reign in the late 19th century, setting up the transfer of power to an emperor.

It has only been in the last century, of course, that we’ve realized just how dangerous lead actually is. That knowledge has resulted from the new ability of scientists to detect it in very tiny amounts and to connect those trace exposures with health problems. In the dawn of lead awareness, governments have banned lead paint and leaded gasoline, moved to replace lead pipes in water systems, squeezed down allowable lead levels in consumer products.

Is this a smart response? Yes, obviously, if we are talking about poison unsafe at all levels. But only if said governments are actively – and honestly – trying to enforcement protective standards. For instance, as reported last year by The Washington Post, when inspections discovered massive lead contamination from pipes in Washington D.C. in 2004, the Bush administration not only issued misleading reassurances but moved to loosen protective measures designed to protect against lead poisoning.

Or consider the discovery of lead in popular lipstick brands sold in the United States. Although some of these products showed clear lead contamination in amounts above EPA safety levels – and although women inevitably swallow some lipstick – the U.S. Food and Drug Administration insists that the lipsticks are perfectly safe.  But as I noted in a recent post for the Knight Science Journalism Tracker, there remains considerable consumer doubt and fear about such findings.

Our leaded history continues to haunt us in this country. Lead-based paint remains in hundreds of residential buildings around the country, especially in poor neighborhoods, and our government seems newly reluctant to fund programs that remove such hazards. And it’s not just a paint-in-the living room problem. As USA Today reported this week, the government has been slow to alert city residents of lead-contaminated soils surrounding their homes, linked to long closed factories.

And to raise a non-urban example, considered the still unresolved petition filed with the EPA last year, trying to force the agency to regulate the use of lead shot in hunting, which advocates say is now killing more than 10 million birds and animals every year, mostly due to consumption of spent lead pellets. contaminated by lead.

“It’s long past time do something about this deadly – and preventable – epidemic of lead poisoning in the wild,” said Jeff Miller, conservation advocate for the Center for Biological Diversity. The government does ban the use of lead pellets in shooting waterfowl but conservationists say this barely touches the problem. Still, the EPA has been notably reluctant to take an this issue angrily opposed by hunting groups, who are already describing the petition as an attack on traditional hunting values.

This is not to suggest that lead problems – or even the worst lead problems – are concentrated in the United States. In 2010, more than 1,300 children were sickened in China by lead exposure from nearby smelting plants, leading to furious protests from their parents against government cover-ups. Not to mention, lead poisoning related to gold-extraction in Nigera, where  where health experts say more than 400 children have died and thousands more been sickened – as a result of lead exposure related to handling of contaminated ores.

The feet, mechanical, go round
A wooden way
Of ground, or air, or ought
, Dickenson wrote in The Hour of Lead and she was writing, of course, of the clock-work motions of those caught in grief. But it strikes me that the mechanical analogy applies here too because we keep repeating these same actions that bring us into harm, as if we cannot seem to fully learn – or fully respect – what our own history should have taught us here.

We remain, thus, in our eternal hour of lead, still not fully awakened from that our lead-induced stupor, apparently, and still unable to let go.

(This is an update of one of my favorite posts, partly because lead is such an important poison, and partly because I managed to weave the poet Emily Dickinson’s wonderful poem into it!)

Category: Speakeasy Science | 18 Comments

National Poison Prevention Week

In December, the U.S. Centers for Disease Control and Prevention (CDC) made this startling announcement: poisoning is now the leading cause of injury deaths in the United States, surpassing even automobile accidents.

The primary reason, as CDC notes, is the rise of opioid pain-killers and their increasing abuse: “During the past three decades, the number of drug poisoning deaths increased sixfold from about 6,100 in 1980 to 36,500 in 2008.”

I mention this because this week (March 18-24) is National Poison Prevention Week, which began 50 years ago in 1962. (That particular year also saw the publication of Rachel Carson’s crusading novel, Silent Spring, which helped galvanize public attention concerning the risks associated with what she recognized as too casual use of industrial and agricultural chemicals.)

We should obviously add to that warning list the too casual use (and abuse) of prescription drugs. In its press release, which I’ve linked to above, the Poison Prevention Week Council notes that emerging hazards “have again ignited the need for increased awareness. In just the past year, America’s 57 poison control centers fielded 4 million calls, treating 2.4 million human poison exposures and handling 1.6 million information calls.”

As readers of this blog know, increased awareness of our chemical world is one of my ongoing crusades. And while I’m not given to public service announcements, I do like to take every opportunity to sound that trumpet. The rise in poison deaths and injuries should remind us that however well informed we may consider ourselves – there is much room to do much better.

For instance –  yes, another a pet crusade of mine – we could reduce carbon monoxide deaths if we would just take more seriously the dangers posed by that odorless, colorless and extremely poisonous gas. On the very first day of poison prevention week, I read this story from California about five people hospitalized with carbon monoxide poisoning due to a heater leak. As the story noted, there were no working carbon monoxide detectors in the house. As the CDC also notes, this gas kills hundreds of people every year and sends an average of 15,000 annually to the hospital in the U.S. alone.

But enough about me and my crusades. There’s a slew of good information this week about protecting yourself – and your pets – from every day toxic substances.

Here, for instance, is some good advice on protecting children from Health News Digest.

Here’s some ways to protect your pet, courtesy of Pet MD.

There’s a smart piece here from Consumer Reports on when to lock away household chemicals.

And an announcement here from the U.S. Environmental Protection Agency (EPA) which summarizes some of the major issues. (Both Canada and Mexico are also participating in poison prevention week.)

Pay attention to this, okay? Oh, and go get that carbon monoxide detector. You don’t want to end up in this blog, do you?

Category: consumer protection, poison | Tagged , , , , , , , | 1 Comment

Cough Syrup, Dead Children, and the Case for Regulation

Kathleen Hobson was eight years old when her mother unknowingly dosed her with poisonous cough syrup. She’d only taken a couple spoonfuls but when investigators came round, they still found nothing left to test.  After the little girl died, her mother had set the bottle on fire and then thrown it into the trash.

Charlene Canady was just four when she died from the same medication. Her father had carefully packed the cough syrup bottle, waiting for justice to come calling.  I always imagine him silent when he handed the bottle over, grief and his daughter’s name caught like a kind of suffocation in his throat.

Both little girls lived in Tulsa, Oklahoma, both came down with nasty little colds in the fall of 1937,  and both died because they were dosed with a brand new medication, a popular, raspberry-flavored cough syrup.  In all, the syrup would kill 11 people in Oklahoma, within a few weeks. Ten in Alabama. Ten in Georgia. Twenty-three in Mississippi. Nine in South Carolina. Seven in Texas. More in California, Ohio, Illinois, Missouri, Virginia, Louisiana, and more.

More than one hundred dead nationwide, in fact, and most of them children, Charlenes and Kathleens scattered across the United States like so much storm wreckage.  “Nobody but Almighty God and I can know what I have been through these past few days,” a Louisiana doctor later wrote to the U.S. Food and Drug Administration, after six of his patients died in one week.

As FDA scientists would quickly realize, the syrup was lethal because it was sweetened by a compound known as diethylene glycol which kills by causing acute kidney damage. Both diethylene glycol and the obviously closely related compound, ethylene glycol (even more toxic) are best known today for their use as antifreeze agents and  homicidal weapons on more than one occasion.

But at the time that Elixir Sulfanilamide came to be, produced by the S.E. Massengill Company of Bristol, Tennessee, that wasn’t well understood.  There was actually no legal requirement that companies understand their products, much less safety test them.

The company chemist who designed the cough syrup by mixing a sulfa drug into the poisonous sweetener claimed to have no such knowledge. And as the company president, Samuel Massengill responded: “We have been supplying a legitimate professional demand and not once could have foreseen the unlooked-for results. I do not feel that there was any responsibility on our part.”

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Category: consumer protection, science history, Speakeasy Science | Tagged , , , , , , , , , , , | 38 Comments

Plumb crazy

The chemical symbol for lead is Pb, from the Latin word “plumbum” which refers to a malleable metal.

And lead is that – soft, malleable, wonderfully conformable, metal of a hundred uses. Its presence – and indeed the very language of lead  – infuses our culture today.  The term plumbing dates back to the use of lead pipes by the Romans. The person who installs and repairs those pipes is called a plumber. A plumb bob refers to a lead weight, a plumb line is pulled straight by such a weight.

Then there’s the word “plumbism” which doesn’t get much use these days. But that happens to be my topic here – plumbism is the  old-fashioned term for lead poisoning, which plagued the Roman empire and continues to plague us today. Some scholars have argued that the Roman’s profligate use of  lead (pipes, bottles, and wine cups, leaded cosmetics and paint) helped put it an end to that empire. An EPA  paper on the subject points out that lead’s neurotoxic contribution is considered a key part of “the conspicuous pattern of mental incompetence that came to be synonymous with the Roman elite.”

Interestingly, Japanese scholars have made a similar case for lead poisoning as a factor in the end of the Edo period in 1867, the decline of the once-powerful  shogunate ruling class.   A recent study by  Tamiji Nakashima, an anatomist at the University of Occupational and Environmental Health in Kitakyushu, and his colleagues analyzed the bones of some 70 samurai men, their wives and children from that period. They had wondered if heavy use of lead-based white face paint had been a health factor and their investigation showed them precisely right; they found evidence of lead levels more than 120 times background level as well as bands of lead deposits in the bones.

Of course, they didn’t know what we’ve learned in the intervening years. “No safe blood lead level has been identified,” according to a current U.S. Centers for Disease Control and Prevention (CDC) backgrounder on exposure risks.

The wonderfully useful metal lead is also a wonderfully broad spectrum poison – it interferes with enzyme production, especially enzymes needed by red blood cells, and is known to cause lethal anemias. It deposits itself into bones and stays there – the half-life of lead in human bones is up to 30 years. Muscle weakness, numbness and tingling, nausea, severe stomach pain, depression, fatigue, sleeplessness, loss of libido – all are symptoms of lead poisoning and all speak to its ability to impact every part of the body.

It is also a notorious neurotoxin. We understand, as the Romans did not, that this happens in part because lead can destroy production of essential neurotransmitters  (such as glutamate which plays a key role in learning by enhancing plasticity). In this country, we’ve been cataloging lead’s ability to do harm for well over a hundred years – U.S. scientists were diagnosing lead poisoning as early as 1887 – sometimes despite the attempts of industry to deny that work. Last summer, I wrote about some of the early 20th century science, and the resulting controversy,  in a post on the troubled history of leaded gasoline.

I mentioned all these moments from history here because they add up to one clear point: we’ve known that lead was dangerous for a very long time. Eventually, in fact, the evidence was so overwhelming that the federal government banned it from paint in 1978 and started phasing it out of gasoline shortly later (although that process didn’t end in this country until the early 1990s.)

Should that have happened sooner. Yes. Did those bans remove all industrial lead contamination from the environment? No. By some estimates, U.S. use of leaded gasoline sent some 7 million tons of lead into the atmosphere, which obviously precipitated right back down to us. And programs to removed leaded paint from old buildings have been woefully underfunded, especially in the country’s poorest neighborhoods where lead-poisoning of children continues to be reported at dismaying levels.

So why, with all this painfully learned awareness in our hands, why in the name of lead-free sanity would our federal government decide to gut the meager program dedicated to helping protect those very family. Yes, the U.S. Center for Disease Control and Prevention (CDC) Healthy Homes and Lead Poisoning Prevention Program has been slashed from $29 million to $2 million for the next fiscal year.

“There’s a serious irony here,” The New York Times noted, this week, pointing out that new public health guidelines recommend reducing childhood lead exposure to even lower levels than now exist. There’s also the fact that removal of lead paint has dragged on for so long that some tenants are turning to civil lawsuits to force the issue. And the fact that a pilot study in St. Louis found that lead paint removal did, indeed, offer some real protection to families in affected neighborhoods.

In other words, in the scheme of our federal budget, this is a very small amount with a very large proven benefit. So why would our government back away from supporting it. “Poisoned Poor Kids?” wrote a columnist for the Colorado Springs Independent. “Congress Doesn’t Care.” At the, Peter Montague was even more pointed in a piece titled, “Poisoning Urban Children: White Privilege and Toxic Lead.”

In fact, there’s not a single good public health reason to support this cut – and plenty of potential very bad results to follow. I’m writing here to add my own voice to those calling for these funds to be restored. Let hese children and families least receive a slim promise that we are here to protect their well-being and that we actually do care about their futures. They deserve more than that but I’m not optimistic that they’ll get it.

But the mistakes of our poisonous past should remind us here that this is a very wrong direction. Or perhaps we should just call it plumb crazy.


Category: lead, poison, science history, Speakeasy Science | Tagged , , , , , , | 15 Comments

Download the (e-book) Universe

At this January’s remarkable Science Online conference,  the science writer Carl Zimmer, led a discussion of e-books and the future of publishing. And whether the future was, in fact, already here.

Zimmer is one of the most acclaimed science writers working today. He’s also has a gift for making things happen. After the  meeting, he gathered together a group of especially intrigued science writers and proposed that we launch a new venture – a website dedicated to reviewing science e-books.

To a person  we loved the idea. And barely a month after our first discussion, we launched the site, Download the Universe, yesterday with a book-savvy introduction from Carl and a review by me of Theodore Gray’s gorgeous chemistry-focused e-book/app The Elements. You can read Carl’s post about it at his blog, The Loom, here.

I also want to draw your attention to the other founding editors of the project who are some of the best science writers and bloggers in the country. They include, in no particular order, David Dobbs, Jennifer Ouellette, Brian Switek, Annalee Newitz, Sean Carroll, Maia Szalavitz, Steve Silberman, Ed Yong, Maggie Koerth-Baker, Tom Levenson, Eric Michael Johnson, John Hawks, and John Timmer.

Timmer wrote today’s post on the state of the e-book and there are many more in the queue. But if you have an idea of an e-book you’d like to see reviewed, please do share it. We’re talking about the universe, after all, and there’s a lot of territory to cover.

Category: science communication | Tagged , , , , , , , , , , , , , , , | 1 Comment

On rice and arsenic

Source: Wikimedia Commons

Last week, a team of researchers from Dartmouth University released a widely publicized study with the somewhat provocative title  “Arsenic, Organic Foods and Brown Rice Syrup.”

The study was yet another general reminder that words like “organic” or “natural” are not synonymous with the word “safe.”  But more specifically it detailed unexpected amounts of poisonous arsenic compounds in everything from infant formula to snack bars, especially compounds containing rice or sweetened with brown organic rice syrup as a healthier alternative to high fructose corn syrup.

I’ll return to the question of exact amounts later; let us just note for now that all findings were in part per billions,  numbers that may raise concerns about long-term exposure but do not suggest that anyone will be dropping dead after snacking on a cereal bar.

The more interesting immediate question anyway, at least to me, was:  why were Dartmouth chemist Brian Jackson and his colleagues looking for arsenic in these supposedly healthy products at all?  I rapidly discovered though that I just hadn’t been paying attention. They were simply following up on an issue well known in health science, a body of work establishing a troubling connection between rice and arsenic in the food supply.

In fact, my use of the word “unexpected” probably is more accurate in describing dismayed public reaction to the results.  The authors of the new study emphasized that their working hypothesis, from the start, was that  brown rice syrup would introduce arsenic into these foods.

So why rice in particular?

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The Curious (Toxic) Chemistry of Chocolate

The Latin name for the cacao tree – the tropical plant source of all things chocolate – consists of two words packed with candy-loving scientific exuberance.  Theobroma cacao. It derives from the Greek words for god (theo) and food (brosi), roughly translating to  “food of the gods”.

Well, sure you say. Obviously. This is chocolate, after all.  Almost goes without saying. Which is why I won’t. Actually, I’m mostly trying to explain why the  most potent chemical compound  in chocolate – a plant alkaloid, slightly bitter in taste, surprisingly poisonous in some species – is called theobromine.

And while chocolate, as a whole, has a wonderfully seductive  chemistry, this poison-obsessed blog will remain, well, obsessed. Today’s obsession is inspired by  the fact that  every Valentine’s season, in addition to stories about love and lace, newspapers run cautionary candy tales. In the last few days alone, there have been headlines ranging from Chocolate Poisoning and More to  Pets and the Peril of Chocolate.

And that’s entirely due to, yes, theobromine.

So theobromine is an alkaloid, meaning it’s part of the everyday chemistry of the plant world.  Plant alkaloids are nitrogen-based, typically with with flourishes of carbon, hydrogen and occasionally other atoms such as oxygen.  The recipe (or as chemists like to say, formula) for theobromine is seven carbon atoms, eight of hydrogen, four of nitrogen and two of oxygen.

And while this may sound like a recipe for the routine, alkaloids are anything but.  The first plant alkaloid isolated (in 1804) was morphine from the flowering poppy.  Other notable examples include cocaine (1860),  nicotine (1828), caffeine (1820), strychnine (1818) and a host of pharmaceuticals including the anticancer drug Vincristine; the blood pressure medication, reserpine; and the antimalarial compound, quinine.

By this standard, theobromine discovered in cacao beans in 1841, might sound to you

Theobromine, 3-D model

like a basic wuss of the alkaloid family. It’s mostly known as a mild stimulant in humans; it contributes (along with caffeine and a few other compounds) to that famed lift that people get from eating chocolate.

There is some evidence that if people get carried away with chocolate consumption, of course, theobromine will make them a  little twitchy. According to the National Hazardous Substances Database: “It has been stated that “in large doses” theobromine may cause nausea and anorexia and that daily intake of 50-100 g cocoa (0.8-1.5 g theobromine) by humans has been associated with sweating, trembling and severe headache.”  Occasionally, people (mostly the elderly) have needed hospital treatment for a theobromine reaction.

But if one looks at LD50 values, it’s obvious that the alkaloid is far more threatening to other species. LD50 is an oral toxicity measurement; it refers to the dose that will kill 50 percent of a given population and is usually calculated in milligrams of poison per kilograms of body weight.  The theobromine LD50 is about 1000 mg/kg in humans. But for cats it’s 200 mg/kg and for dogs it’s 300 mg/kg – in other words, dangerous at a far lower dose.


This varies, of course, by animal size and shape and breed. A few years ago, in fact, National Geographic published a fascinating interactive chart so that pet owners could search out the individual risk.   The chart focuses on dogs because they are more likely than cats to eat something sweet. And it notes that theobromine is more concentrated in dark chocolates making them more dangerous than milk or “white” chocolate. The dark chocolate effects are so acute for canines, that the alkaloid has been tested with some success as a means of controlling coyote populations. (Interestingly,  rats and mice are much less affected; their theobromine LD50 is much more like that found in humans.)

The different toxicities have to do with the way different species metabolize the alkaloid; humans process it much more efficiently than canines. And in small amounts, theobromine’s effects can make it medically useful.  But even here, it shows complexity. It increases heart rate and at the same time it dilates blood vessels, acting to bring down blood pressure. It can also open up airways and is under study as a cough medication.  It stimulates urine production and is considered a diuretic. It interacts with the central nervous system, although not as effectively as caffeine.

At toxic levels – in a characteristic dog death, for instance – all of this adds up acute nausea, convulsions, internal bleeding and often lethal over-stimulation of the heart. “See a vet immediately” is the message of one cautionary post, titled Toxic Chocolate. Another column, written by a vet, suggests rather hopefully that an evening walk is far more romantic and less likely to feature pet vomit (which she describes in revoltingly foamy detail).

We had that same foamy experience in our household in December, actually, when our dog discovered our son’s holiday stash. We all survived but the humans in the house are a lot more careful about where they leave their chocolate. And this Valentine’s Day, we’re sticking to champagne. Sure, ethanol is also a poison in its own right. But that’s a different story.


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Arsenic and the Forgotten Serial Killer

Mary Ann Cotton (source: Wikipedia Common)

Early this week, a British criminology professor wrote a slightly plaintive essay about the 19th century serial poisoner, Mary Ann Cotton. Why, he wondered, did no one remember the evil Mary Ann and her remarkable homicidal career: poisoning  an estimated 21 people, including her mother, children and five husbands before being hanged in 1873?

In retrospective, I worry that my first reaction to these questions is not what he wanted to elicit.  Oh, yeah, Mary Ann Cotton, I thought. Arsenic.

In the 19th century, arsenic (specifically arsenic trioxide (AsO3), also called white arsenic) was used so often that its nickname was “the inheritance powder.” That began to change in the mid-19th century after chemists – notably a determined British scientist named James Marsh – learned out to detect it in a corpse. Cotton was hanged, in fact, in part due to forensic evidence from the Marsh test.

And then my next thought was, well, yeah, but Cotton was kind of a dreary, sneaky kind of  serial killer, a carefully drab woman who liked to slip into the kitchen and mix arsenic  into porridge, soup, a cup of milk.  The author of the Cotton essay, David Wilson, attempts to give her more flamboyance, arguing she enjoyed the deaths themselves, got a charge out of watching people suffer, that “she was, in other words, a psychopath.”

No argument from me.  Cotton did kill some 21 people including her own children. Even if she didn’t get a charge out of watching, I think we could all agree that she possessed the most famous characteristic of a psychopath: “a profound absence of guilt or empathy.”  Whether she was enjoying herself or whether she just possessed a kind of gray, sneaking evil, it’s the body count that really gives her away.

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