A call for revolution in US science, dino microbes in space, vaginas in the lab

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US science is in a fix, so let’s fix it

“It’s as if the Pope and three leading cardinals held a press conference predicting the collapse of the Catholic church. These people know what they are talking about and …

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Lessons that Last: 200 Pearls and Counting

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PLOS Pathogens Pearls Editor Joseph Heitman reflects on the success of Pearls, an Open Access compendium of the “lessons that last”, and introduces the new Flipboard collection.

The PLOS Pathogens Pearls mini-review series publishes concise reviews (less than 1500 words and a …

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Beating the Odds: Are Goats Better Gamers than Sheep?

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We’re all familiar with the shell game, though many may not recognize it by that name. Popular with street swindlers and sports fans at halftime, it has been annoying those unable to locate which cup the ball is under—most …

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Your germy digital footprints are everywhere. Scientists are watching.

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Looked up something on Wikipedia lately? That may be enough for a computer to guess if you’re sick. According to a new study in PLOS Computational Biology, the most accurate, timely data about how the flu is spreading in the …

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Bony body tube for a bizarre marine reptile

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Prehistoric marine reptiles were a weird lot, especially in light of their lizard-like ancestors on land. You take something that roughly looks like an iguana, and evolve it into the shape of a dolphin (icthyosaurs), or evolve it …

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Chromosomal Clues to Past Pregnancy Loss

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Genetics is, in a sense, timeless. DNA sequences stay mostly the same in an individual over a lifetime. Minus the inevitable somatic mutations, the genome of a fertilized ovum is much the same as that of the 80-year-old it might …

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Claire Underwood From Netflix’s House of Cards: Narcissistic Personality Disorder?

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Last month I used the character of Frank Underwood as a “case study” to illustrate the misunderstood psychiatric diagnosis of Antisocial Personality Disorder, and many of you asked: Well, what about his wife, Claire?

Good question!  You asked, and so …

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This week in PLOS Biology

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In PLOS Biology this week, you can read how two independent research teams have identified a new gene involved in circadian rhythms, and how we can improve the power of participatory medicine.


Circadian rhythms are biological processes which

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Are meta analyses conducted by professional organizations more trustworthy?

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gold standard

Updated April 18, 2014 (See below)

A well done meta-analysis is the new gold standard for evaluating psychotherapies. Meta-analyses can overcome the limitations of any single randomized controlled trial (RCT) by systematically integrating results across studies and identifying and contrasting …

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Awl be Darned: Metal Arrived in the Southern Levant Long Before Previously Thought

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The Copper Age, sometimes referred to as the Chalcolithic period, was a time of technological transition for humans. As stone tools gave way to metal ones, the Levant—which includes parts of modern-day Israel, Palestine, Jordan, Lebanon, and Syria—emerged …

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