How Knowledge Sharing Moves Countries Towards UHC

Stefan Nachuk, Amanda Folsom, and Nathaniel Otoo are members of the Joint Learning Network for Universal Health Coverage (JLN). The JLN provides a forum for countries to learn from one another and work together towards achieving UHC.

JLN LogoAs the global movement towards UHC -as a post-2015 goal- continues to gain momentum, low and middle-income countries will need to overcome a number of design and technical challenges within their health systems to achieve UHC. Health systems strengthening and reform are very challenging– both in terms of designing policies and programs and effectively implementing them to assure the desired impact. There is often a knowledge gap between “how to” implement health systems changes and traditional research methods and technical assistance. Much knowledge about how to effectively design and implement systems change resides in practitioners who have led or are in the process of leading systems, programs, and reform processes.

Almost 5 years ago, practitioners in countries such as Ghana, India, and Thailand who were working to achieve universal health coverage (UHC) in their countries had no way to connect with each other. These practitioners tried to find answers to their implementation challenges within the myriad of articles and reports about universal coverage. They typically found that traditional technical assistance approaches tended to focus on what to implement, not how. There was a paucity of forums specifically designed for them to learn from one another and co-develop new knowledge and solutions about how to achieve UHC.

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Category: General | 2 Comments

Ebola Virus Disease: Platform for North-South Collaboration Urgently Needed

Solomon Nwaka and colleagues summarize the outcomes of the September meeting of the Board, and Scientific and Advisory Committee (STAC) of the African Network for Drugs and Diagnostics Innovation (ANDI) on Ebola, and outline the next steps for combating EVD.

Image credit: NIAID, Flickr

Image credit: NIAID, Flickr

The World Health Organization (WHO) has characterized the current Ebola Virus Disease (EVD) crisis as not just a public health crisis, but also a social, humanitarian and economic crisis, and a threat well beyond the outbreak zones. Indeed, the disease has been reported in Spain and USA. The UN General Assembly has established the United Nations Missions for Ebola Emergency Response (UNMEER), to join governments and international partners to respond to the Ebola outbreak. A number of developed and emerging countries, World Bank, African Development Bank, Philanthropic Foundations, and Non-Governmental Organizations including Doctors Without Borders, have made financial and logistical contributions to control the spread and reduce suffering. These resources have been deployed to provide surveillance and contact tracing, mobile testing facilities, isolation and treatment facilities, medical staff, as well as to help the expedited development of potential therapeutic agents. Despite these efforts, the EVD outbreak in West Africa continues, with over 17,256 cases and 6,113 deaths as of December 4, 2014; and estimates of up to 1.4 million cases of Ebola infection by January 2015.

Within Africa, countries such as Nigeria, The Gambia, and Botswana have made monetary contributions in support of the crisis, while others like Malawi, South Africa and Democratic Republic of Congo have provided medical supplies. The Economic Community of West African States (ECOWAS) is implementing a strategy for accelerated response while the African Union has approved a humanitarian mission called the AU Response to Ebola Outbreak in West Africa (ASEOWA). The long awaited establishment of an African Centre for Disease Control and Prevention (ACDCP) now appears to have been fast tracked by the AU, to help in addressing emergencies in a timely and effective manner. An African Public Health Emergency Fund (APHEF) provided initial support to affected countries, but was inadequate to cope with the rage of the epidemic due to poor subscription by countries.

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Category: Ebola, Global Health, Policy, Public | 2 Comments

Neglected Tropical Diseases that Kill

According to the latest (November 28) figures from the World Health Organization (WHO) and US Centers for Disease Control and Prevention, almost 6,000 people have died so far in the 2014 Ebola outbreak in West Africa, with estimates that the deaths will easily exceed 7,000 deaths before year’s end.

There is no question that Ebola virus infection is one of the most lethal of all of the neglected tropical disease (NTD) pathogens, but on a global scale there are a number of other NTDs that also cause large numbers of deaths.

The WHO currently lists 17 major disease conditions as NTDs.  Shown in Fig. 1 is an illustration from our previous publication in PLOS Neglected Tropical Diseases that compares the proportion of disability-adjusted life years (DALYs) that result either from disability (YLDs – years lived with a disability) colored in blue, or death (YLLs – years of life lost) colored in orange.   It’s clear that there is a lot more blue than orange meaning that most of the world’s NTDs are disablers rather than killers.  But there are also important exceptions such as the kinetoplastid infections, including leishmaniasis (kala-azar), African sleeping sickness, and Chagas disease, as well as the viral infections rabies and dengue fever which also represent major killers.  Schistosomiasis, which is a major disabler, is another important cause of mortality in Africa.

Hotez et al.

Hotez et al.

Indeed, if we compare the number of people who have died in this year’s Ebola epidemic with the number of deaths caused by NTDs from the Global Burden of Disease Study 2010, we find that there are some very serious and lethal NTDs that get very little attention.  At least six NTDs kill more people each year than all those who perished from Ebola virus infection this year.

Our takeaway is that while we urgently need new drugs, diagnostics, and vaccines for Ebola virus infection, the same could be said for all of the NTDs listed in Table 1.  As the global policy leaders in the United States, Europe, and elsewhere meet in the coming weeks and months, we hope they will consider new Ebola virus technologies in the context of each of our planet’s killer NTDs.

Table 1. Deaths from the NTDs and Ebola virus infection (modified from Refs. 1 and 3)

Neglected Tropical Disease Deaths Year
Leishmaniasis 51,600 2010
Rabies 26,400 2010
Dengue fever 14,700 2010
Schistosomiasis 11,700 2010
Chagas disease 10,300 2010
African trypanosomiasis   9,100 2010
Ebola virus infection 6,000-7,000 2014
Intestinal nematode infections   2,700 2014
Cysticercosis   1,200 2014
Echinococcosis   1,200 2014
Category: General | 5 Comments

Ebola: MSF Should Not Replace Governmental Responsibilities

A version of this was published in Le Temps on 31 October 2014

Thomas Nierle and Bruno Jochum of Médecins Sans Frontières emphasize the responsibility of governments to lead the response to disasters like the Ebola outbreak.

Image credit: Francois Dumont/MSF

Image credit: Francois Dumont/MSF

MEP Charles Goerens, rapporteur on Ebola to the European Parliament’s Committee on Development, recently declared (audio report in French) in a European Council meeting that this epidemic is “the first major international crisis in which the lead should be given to an NGO – in this case, Médecins Sans Frontières”.

Given that we have repeatedly called for greater leadership from the international community, including the European Union, this proposal took us by surprise. We have interpreted this appeal, coming from an MEP who has also publicly criticised the inadequate reactions of European states in the face of the epidemic, as a symptom of the failure of existing public response mechanisms and even more so, of the huge collective difficulty in taking action.

When a disaster occurs – whether an epidemic, a natural disaster or any other event with similar effects – the primary responsibility for helping the victims as quickly as possible and minimising the impact on society falls on the affected states. Because public authorities are in the front line for initiating and managing the emergency response, the legitimacy to act can only lie with governments and their collective institutions, as embodied by the United Nations. Not addressing a critical health crisis and therefore abstaining from coordinating healthcare for entire populations would represent utter failure on behalf of States and international institutions whose mandate it is. Such a vacuum would be as worrying as it would be politically unacceptable.

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Category: Ebola, Global Health, MSF | Tagged | 2 Comments

Push for Better Death Data Bears Fruit: Largest Ever Global Dataset of Individual Deaths Released

Jocalyn Clark @jocalynclark comments on the INDEPTH Network’s release of the largest ever dataset of individual deaths in Africa and Southeast Asia, and the importance of equality in health data.

Enthusiasts of global health research will have observed various battles over the years about ‘the best’ health data and estimates. On one side are sophisticated mathematical models arising from advanced statistical techniques but often patchy data, including the massive Global Burden of Disease (GBD) studies.

On another side are on-the-ground collections of individual deaths, using techniques such as verbal autopsy where data collectors actually interview the family members of the deceased and determine cause of death. In 2010 PLOS Medicine devoted a Collection (which I commissioned) to the global health estimates debate, much of which seems highly relevant four years later.

Both types of health information generate insights into the patterns and magnitude of different diseases around the world. And in truth these ‘sides’ should not be pitted against each other – as their estimates and data complement each other. For death data in particular, there appear to be shared aims to generate better quality and more accurate information about what people die from, not least because it helps us determine which interventions and investments are needed to prevent those deaths. Nevertheless, how and by whom global mortality estimates are generated can often inspire anxiety and antagonism.

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Category: General | 3 Comments

Does Exposure to Smoking (Either Passive or Active) Lead to Increased Allergies?

Charles Ebikeme interviews Dr. Bahi Takkouche of the University of Santiago de Compostela and reviews his research on smoking and allergies, which was published earlier this year in PLOS Medicine.

Dr. Takkouche’s paper is included in the PLOS Clinical Immunology Collection, which is organized into broad categories in response to the commonly articulated request from our users that we provide more structured and efficient access to papers of interest in the PLOS corpus. The Collection has been updated today with two new sections on Immunodeficiency and Autoimmune Diseases.

Smoking is one of the most common factors when you think of allergens. Its link to a whole host of diseases within the atopic march – the cascade of allergies that starts with allergic dermatitis (such as eczema) during infancy, progresses to allergic rhinitis (for example hay fever) and food allergies, and finally exhibits with asthma – has been heavily researched. But unfortunately, no clear consensus exists as to the causes.

Research published in PLOS Medicine in March of 2014 took a wide look at the data from all published research on the theme of tobacco smoking and its relation to allergies. The sheer volume of amassed and analysed knowledge often makes it difficult for good recommendations to be made to practitioners on the risks involved with – let alone other researchers in the field wanting to see where their work fits in the landscape. A meta-analysis like this allows all studies to be assessed together, and gives a clearer picture of the research landscape.
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Category: General | 6 Comments

An Interview with Pascale Cossart

Charles Ebikeme interviews Pascale Cossart of the Institut Pasteur on the occasion of her receipt of the Women in Science Award at FEBS-EMBO 2014.

Pascale CossartOn September 2, Pascale Cossart received the Women in Science Award at the Federation of European Biochemical Societies / EMBO 2014 conference.

On October 23, Cossart and colleagues published “Listeria monocytogenes Dampens the DNA Damage Response” in PLOS Pathogens, in which she describes a toxin that blocks the body’s response to bacterial induced DNA, a crucial step for a productive infection.


Why did you decide to become a scientist? What drew you to the field?

At the beginning I decided to become a scientist because I loved science. I was interested in chemistry. But after two weeks in a chemistry lab I realized that maybe I loved it on paper, but I had the feeling that the big period of chemistry was somehow over. I was in organic chemistry and polymer chemistry, then I took a course — par hasard — of biochemistry, and then I went to my professor and I switched–and that was it. But I never had any other aim than doing research. I remember that my parents were telling me that I could make more money in industry instead of having this little fellowship.

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Category: General | Tagged , , , | 1 Comment

Pneumonia Affects People of All Ages: Interview with Carlos J. Orihuela

For World Pneumonia Day 2014PLOS Pathogens interviews Associate Editor, author, and researcher Carlos J. Orihuela on his recent publication in PLOS Pathogens, Streptococcus pneumoniae Translocates into the Myocardium and Forms Unique Microlesions That Disrupt Cardiac Function, describing how the disease can lead to heart damage in the elderly.

High powered magnification of the 30 h cardiac microlesion shows S. pneumoniae bacterial aggregates within the microlesion.

High powered magnification of the 30 h cardiac microlesion shows S. pneumoniae bacterial aggregates within the microlesion.

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What Factors Might Have Led to the Emergence of Ebola in West Africa?

This manuscript has been conditionally accepted by PLOS Neglected Tropical Diseases for publication prior to formal review. Following a successful outcome of independent peer review, a revised version will be formally published by PLOS Neglected Tropical Diseases and a link to the final article posted here. Read more here

A PDF of the full text is available: Alexander et al.

What factors might have led to the emergence of Ebola in West Africa?

K.A. Alexander¹, C.E. Sanderson¹, M. Marathe2,3, B.L. Lewis³, C.M. Rivers³, J. Shaman4, J.M. Drake5, E. Lofgren³, V.M. Dato6, M.C. Eisenberg7, and S. Eubank³

1 Department of Fisheries and Wildlife Conservation, Virginia Tech, Blacksburg, Virginia

2 Department of Computer Science, Virginia Tech, Blacksburg, Virginia.

3 Network Dynamics and Simulation Science Laboratory, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia.

4 Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York

5 Odum School of Ecology, University of Georgia, Athens, Georgia

6 Department of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

7 Departments of Epidemiology and Mathematics, University of Michigan, Ann Arbor, Michigan


An Ebola outbreak of unprecedented scope emerged in West Africa in December 2013 and presently continues unabated in the countries of Guinea, Sierra Leone, and Liberia. Ebola is not new to Africa and outbreaks have been confirmed as far back as 1976. The current West African Ebola outbreak is the largest ever recorded and differs dramatically from prior outbreaks in its duration, number of people affected, and geographic extent. The emergence of this deadly disease in West Africa invites many questions, foremost among these: Why now and why in West Africa? Here, we review the sociological, ecological, and environmental drivers that might have influenced the emergence of Ebola in this region of Africa and its spread throughout the region. Containment of the West African Ebola outbreak is the most pressing, immediate need. A comprehensive assessment of the drivers of Ebola emergence and sustained human-to-human transmission is also needed in order to prepare other countries for importation or emergence of this disease.  Such assessment includes identification of country-level protocols and interagency policies for outbreak detection and rapid response, increased understanding of cultural and traditional risk factors within and between nations, delivery of culturally embedded public health education, and regional coordination and collaboration, particularly with governments and health ministries throughout Africa. Public health education is also urgently needed in countries outside of Africa in order to ensure that risk is properly understood and public concerns do not escalate unnecessarily. To prevent future outbreaks, coordinated, multiscale, early warning systems should be developed that make full use of these integrated assessments, partner with local communities in high-risk areas, and provide clearly defined response recommendations specific to the needs of each community.

Competing Interests: The authors have declared that no competing interests exist.

Funding: The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.This work has been partially supported by DTRA CNIMS Contract HDTRA1-11-D-0016-0001. Research reported in this publication was partially supported by the National Institute of General Medical Sciences of the National Institutes of Health under award number 5U01GM070694-11 and U01 GM110748 as well as the RAPIDD program of the Science and Technology Directorate, US Department of Homeland Security and the NLM Pittsburgh Biomedical Informatics Training Grant 5T15 LM007059-28.

Copyright: © 2014 Alexander et al. This is an open-access manuscript distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Category: Ebola, General | 9 Comments

Mind the Deadly Gaps

Grania Brigden (@TBBrigden) discusses the urgent need to close the gaps in the TB response.

Image Credit: Treatment Action Group

Image Credit: Treatment Action Group

The 45th Union World Conference on Lung Health held in Barcelona last week opened with the Health Ministers of South Africa and India making bold statements and commitments to address and reverse the TB epidemics in their countries. Five other countries also committed to ending TB, resulting in the birth of the Barcelona Declaration on TB.

This political commitment is desperately needed. The recently published WHO Global TB Report 2014 highlighted not only the increasing numbers but also the growing crisis in tackling drug-resistant TB. The reality for those infected with multi-drug resistant TB (MDR-TB) is that they have only a one in eight chance of being identified, correctly diagnosed, started on treatment and cured. This is not acceptable.

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Category: General, MSF, Tuberculosis | Tagged | 2 Comments