This is a large publishing week for PLoS Medicine, featuring 3 new Research Articles and 3 new Magazine pieces, including an update to the World Health Report 2012: No Health Without Research collection.
Madhavi Bajekal and colleagues examine trends in coronary heart disease mortality in England between 2000 and 2007, across and within socioeconomic groups.
A cost-effective analysis by Edwine Barasa and colleagues reports that a complex intervention aimed at improving quality of pediatric care would be affordable and cost-effective in Kenya.
In a randomized trial, Shahin Lockman and colleagues compare nevirapine-based therapy with lopinavir/ritonavir-based therapy for HIV-infected women without previous exposure to antiretroviral treatment.
Rosanna Peeling and colleagues describe their experience of introducing point-of-care testing to screen for syphilis in pregnant women living in low- and middle-income countries.
Susan Ellenberg discusses alternative approaches towards evaluating data as it accumulates in clinical trials, and to protecting the integrity and preventing undue risks to participants as the trial continues.
As part of a cluster of articles leading up to the 2012 World Health Report and critically reflecting on the theme of “no health without research,” Trudie Lang and Sisira Siribaddana discuss the value and challenges of doing clinical trials in developing countries.