This Week in PLoS Medicine: Tuberculosis diagnostics; LED-FM microscopy; Incremental cost-effective ratios

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Three new articles publish this week in PLoS Medicine, including two related studies on tuberculosis by Luis Cuevas and colleagues.

Luis Cuevas and colleagues report findings from a multicenter diagnostic clinical trial in tuberculosis, showing that the sensitivity and specificity of a “front-loaded” diagnostic scheme is not inferior to that of a standard diagnostic scheme.

A cross sectional study by Luis Cuevas and colleagues, nested within a clinical trial, finds that LED-FM microscopy has higher sensitivity but lower specificity than Zn microscopy for detecting tuberculosis in sputum samples.

John Ioannidis and Alan Garber discuss how to use incremental cost-effectiveness ratios (ICER) and related metrics so they can be useful for decision-making at the individual level, whether used by clinicians or individual patients.

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