This Week in PLOS Medicine: Preeclampsia & Diabetes, Ugandan Trauma Centers, & Sodium Bicarbonate during Open Heart Surgery

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This week PLOS Medicine featured research and discussion on Preeclampsia as a risk factor for diabetes. A case study of trauma centers in post-conflict Uganda and research on prophylactic sodium bicarbonate during open heart surgery were also published.

Denice Feig and colleagues assessed the association between gestational diabetes, gestational hypertension, and preeclampsia and the development of future diabetes in a database analysis of pregnant women in Ontario, Canada. The findings suggest that both preeclampsia and gestational hypertension without gestational diabetes are associated with a 2-fold increased incidence of diabetes in the years following pregnancy, after controlling for several important variables. Thach Tran discusses the results and whether women with a history of hypertensive disorders in pregnancy should be screened for diabetes.

In a double-blinded randomized controlled trial, Anja Haase-Fielitz and colleagues found that an infusion of sodium bicarbonate during open heart surgery did not reduce the risk for acute kidney injury, compared with saline control. The researchers stress the need for discontinuation of this prophylactic therapy.

As one article in an ongoing series on Global Mental Health Practice, Etheldreda Nakimuli-Mpungu and colleagues describe a private-public partnership that implemented and scaled psycho-trauma centers in Northern Uganda. This case study offers valuable information on treating depression, post-traumatic stress disorder, and other mental, neurological, and substance use disorders in post-conflict low- and middle-income countries.

In light of this week’s articles on mental health, diabetes, and heart disease, PLOS Medicine reminds readers of our call for papers into research and commentary on noncommunicable diseases (NCDs) directed toward improving population health and reducing health disparities. Information on open calls can be found here.

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