Skip to content

When you choose to publish with PLOS, your research makes an impact. Make your work accessible to all, without restrictions, and accelerate scientific discovery with options like preprints and published peer review that make your work more Open.

PLOS BLOGS PLOS Biologue

Spinal Cord Injury, Gut Microbiome, and White-Plague Coral Disease: the PLOS Comp Biol June Issue

Here are some highlights from June’s PLOS Computational Biology

 

Inference of Network Dynamics and Metabolic Interactions in the Gut Microbiome

June Issue Image: Handmade painting representing FAAH bound to the membrane. Image Credit: Painting by Giulia Palermo with digital manipulation by O'Reilly Science Art, LLC
June Issue Image: Handmade painting representing FAAH bound to the membrane. Credit: Painting by Giulia Palermo with digital manipulation by O’Reilly Science Art, LLC

The community of bacteria that live in our intestines (called the “gut microbiome”) is important to normal intestinal function, and the destruction of this community has a causative role in diseases including obesity, diabetes, and even neurological disorders. Reka Albert and colleagues use a mathematical model to identify how the normal bacterial community interacts and how this community changes with antibiotic treatment and C. difficile infection.

 

A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury

 

People with spinal cord injury are predisposed to pressure ulcers. These ulcers remain a significant burden in cost of care and quality of life, despite improved mechanistic understanding and advanced interventions. Yoram Vodovotz and colleagues create a virtual pressure ulcer as a platform to test therapies and determine the mechanisms most correlated with unfavourable outcomes. Their analysis reveals that inflammation is an important determinant of ulcer severity and overall tissue damage.

 

Coral colonies from the genus Favia infected with white-plague disease. Credit:  Zvuloni et al.
Coral colonies from the genus Favia infected with WPD. Credit: Zvuloni et al.

 

Modeling the Impact of White-Plague Coral Disease in Climate Change Scenarios

 

Coral reefs are deteriorating at alarming rates, with coral disease outbreaks increasing in prevalence and in special distribution. Anomalously high ocean temperatures are thought to significantly contribute to this problem. Yael Artzy-Randrup and colleagues have collected a unique dataset of a White Plague Disease (WPD) outbreak from the coral reef of Eilat (Israel, Red Sea). By fitting a novel epidemiological model to the data, they characterize the dynamics of WPD, and study the possible effects of future increasing sea-surface temperatures on disease dynamics.

Leave a Reply

Your email address will not be published. Required fields are marked *


Add your ORCID here. (e.g. 0000-0002-7299-680X)

Back to top